Nick and Audrey are framed for murder during their long-delayed honeymoon. The preview shows the couple attempt to prove their innocence as they take on the real killer.
"The only thing I love more than a new movie with Jennifer Aniston and @AdamSandler is when I get the exclusive trailer for it. #MurderMystery is on @Netflix June 14th!" DeGeneres tweeted Friday.
Murder Mystery co-stars Luke Evans, Gemma Arterton, John Kani, Ólafur Darri Ólafsson and Terrence Stamp. The movie premieres June 14 on Netflix.
Sandler and Aniston previously co-starred in the 2011 film Just Go with It.
Sandler will host Saturday Night Live for the first time May 4 and will kick off his 100% Fresher comedy tour May 31 in Minneapolis, Minn. Aniston will also star in the new Apple series The Morning Show with Steve Carrell and Reese Witherspoon.