Close previously appeared in Howard's 1994 newspaper comedy, The Paper.
"J.D. Vance, a former Marine from southern Ohio and current Yale Law student, is on the verge of landing his dream job when a family crisis forces him to return to the home he's tried to forget," a synopsis said.
Adams, recently seen in the Oscar contender Vice, will play Vance's mother and Close will portray his grandmother. The role of Vance has not been cast.
Howard's credits include Solo, Frost/Nixon and A Beautiful Mind.