The Hollywood Reporter confirmed Tuesday the 41-year-old actor will appear in Lee's new film Da 5 Bloods.
Delroy Lindo, who collaborated with Lee on Malcolm X, and French actor Jean Reno will co-star. The film follows a group of Vietnam veterans who return to the jungle to find their lost innocence and repair their broken selves.
Deadline said Lee wrote the script with Kevin Willmott from a screenplay by Danny Bilson and Paul DeMeo and a rewrite by Matthew Billingsley. Lee will produce with Beatriz Levin, Lloyd Levin and Jon Kilik.
Lee's first Netflix series, She's Gotta Have It, premiered on the streaming site in November 2017. The show is based on the director's 1986 film of the same name and stars DeWanda Wise and Anthony Ramos.
Boseman is known for playing T'Challa, aka Black Panther, in the Marvel movie Black Panther. He will reprise the role in Avengers: Endgame and also star in the new film 17 Bridges with Taylor Kitsch and Sienna Miller.