The clip, released on Friday, features Baldwin and Hayek sending their daughter off to college when they return home to find a repo man taking their car.
Baldwin and Hayek discover they are running out of money and devise a number of schemes in order to get their daughter through college including holding a yard sale and renting out their neighbors lavish house.
Jim Gaffigan, Joe Manganiello, Ben Platt and Michelle Veintimilla also star. Fred Wolf is directing based off a script he co-wrote with Peter Gaulke.
Drunk Parents will be available on DirecTV on March 21 before arriving in theaters on April 19.