The clip, released Wednesday, features Myers walking the streets of his old neighborhood on Halloween night after escaping from a mental hospital. Myers quickly reverts back to his serial killing ways and obtains his signature weapon, a butcher knife.
Strode, meanwhile, is seen pleading with her adult daughter about being prepared for Myers' return. Strode, who has been training for this moment, is seen using various firearms as she confronts her brother one final time.
"He is a killer, but he will be killed tonight," Strode says.
Halloween, from director David Gordon Green, who co-wrote the script with Danny McBride, is set to hit theaters on Oct. 19.