The 60-year-old actress and 62-year-old writer and producer attended the Los Angeles premiere of Pfeiffer's movie Ant-Man and the Wasp at the El Capitan Theatre.
Pfeiffer turned heads in a sleeveless black jumpsuit with shimmering threads. The star was all smiles she held hands and posed for photos with Kelley.
Paul Rudd, Evangeline Lilly, Michael Douglas, Judy Greer and Tip "T.I." Harris were among the other stars in attendance. Pfeiffer plays Janet van Dyne, the mother of Hope van Dyne (Lilly), in the film, which opens July 6.
"I've always been such a Paul Rudd fan, and the movie was really smart and really funny," the actress told News 18 this month.
"[It also] had this very unusual tone to it that I think set it apart from a lot of the other superhero movies that I had seen," she added.
Pfeiffer married Kelley, the creator of The Practice and Ally McBeal, in November 1993. The couple are parents to 25-year-old daughter Claudia Rose and 23-year-old son John Henry.