Hart, now 81, served as a U.S. senator from Colorado from 1975 to 1987.
"The Front Runner chronicles the rise and fall of politician Gary Hart, who was considered the front-runner for the 1988 Democratic presidential nomination when his campaign was sidelined by the story of an extramarital relationship with Donna Rice. As tabloid journalism and political journalism merged for the first time, Senator Hart was forced to drop out of the race," a synopsis of the movie said.
The big-screen adaptation of Matt Bai's 2014 book All the Truth Is Out will also feature Vera Farmiga, J.K. Simmons, Mamoudou Athie, Josh Brener, Kaitlyn Dever, Tommy Dewey, Molly Ephraim, Spencer Garrett, Ari Graynor, Toby Huss, Mike Judge, Alex Karpovsky, Mark O'Brien, Sara Paxton, Kevin Pollak and Steve Zissishe.
"Having grown up wandering around the Columbia lot as a kid, it is a particular thrill to bring The Front Runner back home to the first studio I can remember. I cannot wait for moviegoers to see Hugh's humanist transformation into one of the more complicated political figures of our time," Reitman -- who is the son of the late filmmaker Ivan Reitman -- said in a statement.
The Front Runner is scheduled for a fall, theatrical release.