Non-Stop and The Shallows director Jaume Collet-Serra will helm the project. Star Trek 4 writers J.D. Payne and Patrick McKay penned the original script, with Logan screenwriter Michael Green later brought on as writer.
Johnson will produce the film with Dany Garcia, Hiram Garcia, Beau Flynn, John Davis, John Fox and Scott Sheldon, according to The Hollywood Reporter. Disney plans to begin production on the project in the spring.
"So happy," Johnson tweeted of Blunt's casting. "All aboard my lovely lady, for the adventure cruise of a lifetime. Trust me... what would possibly go wrong? #BluntJohnson #JungleCruise."
The Jungle Cruise ride takes park-goers on a "tour" through several world rivers, including the Amazon in South America and the Nile and Congo in Africa. Details on the movie's plot are being kept under wraps.
Blunt will also star in Disney's forthcoming Mary Poppins sequel, Mary Poppins Returns.