"I have a lot of unrealized dreams," Clarke said before adding, "I would love to play Jane Bond. My ultimate leading man would be Leonardo DiCaprio. No doubt about it."
The X-Files star Gillian Anderson and Quantico actress Priyanka Chopra are among the other female stars interested in the role. Anderson addressed casting rumors last week after a fan-made poster suggested she portray Bond.
"Well, it's not news, it's a fantasy," she clarified. "Someone made a fabulous poster and it started an intriguing conversation. Will it ever happen in the real world? More than probably not."
Clarke is best known for playing Daenerys Targaryen, aka Khaleesi, on the HBO series Game of Thrones. The actress shared a throwback video of herself singing and dancing with co-star Joe Naufahu, who portrayed Khal Moro, on Monday.