According to The Hollywood Reporter, the comedy which will be directed and produced by Bateman, centers on a successful businesswoman (Aniston), who must introduce her husband (Bateman) to her company executives before she is considered for a high-end CEO position.
Written by Andrea Seigel, the film will mark the fifth time the two stars appear on-screen together in a comedy following 2006's comedy The Break-Up, both Horrible Bosses films in 2011 and 2014 and the 2010 romantic comedy, The Switch directed by Josh Gordon and Will Speck.
In February, the duo signed on for Gordon's and Speck's newest project, Office Christmas Party, alongside comedians Kate McKinnon and T.J. Miller.
Bateman made his directorial debut with the film Bad Words and most recently helmed The Family Fang starring Nicole Kidman.
Significant Others currently has no set release date.