The 47-year-old Friends star plays Sandy, a recently divorced mom with two sons, while Hudson portrays Jesse, a mother-of-one who is estranged from her own mom.
Julia Roberts co-stars as Miranda, a successful businesswoman and author, with Jason Sudeikis as Bradley, a single dad to a teenage daughter. The characters' stories intertwine as Mother's Day approaches.
Pretty Woman and The Princess Diaries director Gary Marshall helmed the film, which opens in theaters Apr. 29. Timothy Olyphant, Hilary Duff, Britt Robertson and Shay Mitchell also have roles.
"There's something about [her]," Hudson said of her own mother, actress Goldie Hawn, to Closer magazine in 2014. "She's very strong-minded, very tough and can be strict, but she's also so forgiving and non-judgmental."
Hudson herself is mom to 12-year-old son Ryder and 4-year-old son Bingham, while Roberts is mother to 11-year-old son Phinnaeus, 11-year-old daughter Hazel and 8-year-old son Henry. Mother's Day falls on Sunday, May 8 in 2016.