"She almost made me toothless because she hit me with a deer hoof," the Modern Family star said about the Oscar-winning actress.
Witherspoon responded, "I was trying to cover myself with a deer skin and it flopped over and hit her in the teeth. It was bad...That was like the second day of shooting and I thought she was going to quit. It wasn't funny."
That wasn't the only physical infraction the comedic duo encountered while filming. Witherspoon endured some injuries herself, when Vergara sent the Wild star to the hospital for a possible popped ovary.
Vergara jokingly responded, "I really didn't care. I just wanted to make sure she was not going to delay everything, that she was going to show up on the set the next day." She said, "Accidents happen when you're doing this kind of high-intensity [work]."
Hot Pursuit opens in theaters May 8.