The event is to mark the 25th anniversary of Martin Scorsese's iconic gangster picture.
A screening of the movie at New York's Beacon Theatre is to be followed by a question-answer session featuring the artists who made it. Jon Stewart will moderate the event, which will close the 14th edition of the festival April 25.
"While TFF's mission is centered around new stories and voices, we also seek to honor the creators and films that have shaped the cultural landscape," Jane Rosenthal, co-founder of the Tribeca Film Festival, said in a statement Wednesday. "GoodFellas is one of those pictures with an honest and stylized portrayal of the gangster lifestyle that has inspired a generation of filmmakers and television directors across genres. We are proud to celebrate its 25th anniversary at our closing night and introduce new audiences to one of Marty's masterpieces."
"I was so excited to learn that this picture, now 25 years old, would be closing this year's Tribeca Film Festival. Excited and moved," added Scorsese. "It was an adventure to get it on screen -- we wanted to make a movie that was true to Nick Pileggi's book and to the life of Henry Hill and his friends, which means that we broke some rules and took some risks. So, it's heartening to know that GoodFellas has come to mean so much to so many people. It's wonderful to see one of your pictures revived and re-seen, but to see it closing Tribeca, a festival of new movies, means the world to me."
"I was most proud of this film 25 years ago, and equally proud of it now. I'm very happy that it is our closing night film," said De Niro, co-founder of the festival.
Warner Bros. Home Entertainment will release GoodFellas 25th Anniversary on Blu-ray and Digital HD May 5. The new set will feature a documentary called Scorsese's GoodFellas, which includes interviews with De Niro, Liotta, Leonardo DiCaprio and Harvey Keitel.