Reubens, 62, offered a few details about the long-gestating project during a visit to The Tonight Show Starring Jimmy Fallon last Wednesday.
"Judd Apatow is producing it," Reubens said. "We hired a director -- I can't say yet -- but we've hired a director and we're going to start in February."
The plot and other cast members were not disclosed.
The comedian played the title character in the 1985 cult classic comedy Pee-wee's Big Adventure and its 1988 sequel Big Top Pee-wee, as well as in the children's program Pee-wee's Playhouse and numerous stage incarnations. He took a break from his alter-ego for several years after he was arrested for indecent exposure at an adult movie theater in 1991.