Organizers confirmed Wednesday on Twitter that Shelton, 44, and Stefani, 50, will perform their duet "Happy Anywhere" at the awards show Sept. 16.
"They'd be 'Happy Anywhere' but, lucky for you, @blakeshelton and @gwenstefani will be at the #ACMawards NEXT WEDNESDAY!" the post reads.
Shelton had shared the news in a tweet Tuesday.
"'Happy Anywhere' with @gwenstefani is coming to y'all live from the @ACMawards," he wrote.
"I'm honored to perform 'I'll Carry You Home' @ACMawards on September 16, paying tribute to those we have lost in the Country Music industry," she tweeted.