The trio parodied a soap opera love triangle in a sketch, "The Longest Days of Our Lives, via video chat during Wednesday's episode of the series.
Fallon and Wiig played a couple, Winston and Vanessa, who were living apart amid the coronavirus outbreak. Vanessa shocked Winston by confessing she had cheated on him.
"How could you?!" Winston responded. "I mean, how could you? We're all social distancing and quarantining. Was it through, like, Skype or something?"
Vanessa then admitted her lover was Winston's brother. Enter Ferrell, who portrayed Winston's brother, Alejandro, Winston's long-lost brother, Montgomery, and "another other brother," Fontaine.
"I'm Fontaine, your other other brother. We have the same mother. We're evil twins of each other," Fontaine said. "And I'm your lover's lover."
"That has given me so much life, and just so much joy," the actress said. "It reminds me why I do what I do -- those people were definitely touched in some kind of way by these characters, so much so that they did a whole TikTok and had to learn the timing."
"it was fun! I'd never done action comedy before," Henson said. "[Ed and I] had an incredible time. I think we had great chemistry."
In addition, singer Dua Lipa performed her single "Break My Heart" during Wednesday's episode.