The ad, released on Tuesday, begins with the late night host and former WWE star lifting weights until Fallon accidentally throws one through a glass window.
Fallon, feeling down about working out, is encouraged by Cena to see the lighter side of exercising while enjoying a Michelob Ultra at a bar.
Fallon then imagines his Tonight Show band The Roots encouraging him to keep running during a performance and imagines meeting former Olympian Usain Bolt.
"I'm so proud I could squat you," Cena says after Fallon runs football drills. Fallon, back at the bar, appears happier but is recovering from all the physical activity by standing in a tub of ice.