Longoria, 44, and Moore, 58, discussed the movement against sexual assault, harassment and inequality in the workplace during Thursday's episode of Watch What Happens Live.
Longoria and Moore have been active in Time's Up since the movement was founded in January 2018 in response to the Harvey Weinstein sexual assault and harassment allegations and the #MeToo movement against sexual violence.
"For me, I love the global awareness we've created," Longoria said. "We took some sex scandal and made it a movement, as opposed to it just sort of going away after the Harvey thing. It just really changed not only our industry but all industries."
"When we launched, we united with farmworkers, restaurant workers, domestic workers, hotel workers, fast food workers -- women everywhere encounter sexual harassment at a crazy percentage," she added. "So I think [I'm proudest of] the global awareness to talk about it first and then to make change."
Longoria and Moore said the gender pay gap remains one of Time's Up's concerns. Moore said she is proud of how Time's Up helped persuade New York Gov. Andrew Cuomo to adopt the New York Time's Up Safety Agenda, which is an initiative to prevent sexual harassment and assault and help survivors seek justice.
"For all of us in New York, I think we're proudest that Cuomo has just adopted the Time's Up Safety Agenda, which extends statute of limitations on sexual assault," Moore said. "We really feel proud of what we've done."
Reese Witherspoon, Meryl Streep, Jennifer Aniston, Natalie Portman, Emma Stone, Oprah Winfrey and Olivia Munn are among the other stars to support Time's Up. Munn said in an interview in June that stress about the direction of the movement and doing right by survivors has caused her health problems.
"One of the things that stresses me out more than anything is how do we do right by [the silence breakers]?" the actress said. "We can't tell stories about people and then not care about them."