Chopra and Markle became fast friends after meeting at the 2016 Elle Women in Television dinner. At the time, Chopra starred on the ABC series Quantico, while Markle had a lead role on the USA Network show Suits.
"Megs... she was always meant for big things," Chopra said of Markle.
"To be a change and be an important voice in doing that. It's amazing that she found that calling and has the platform to be able to do it," she added of Markle's charity work and other projects.
Markle married Harry in May 2018 and gave birth to their first child, son Archie Harrison, this May. Chopra spoke to Elle during Markle's pregnancy.
"By the time this comes out, she will have a baby -- it's so amazing how lives change," she said of Markle, who became the duchess of Sussex after her marriage to Harry. "I'm a big believer in taking charge of your life, but there's got to be something bigger that puts us into the circumstances that we are put in. Destiny has a weird was of helping you to find your calling."
"It's so different," the star said.
"I'd never realized having a husband and a boyfriend are such different things," she added. "When you say your vows, it's like, this person is my family, and it's the family I chose. There's a weird responsibility to them. And a safety that comes from it. We are learning about each other every day."