Preview performances are scheduled to begin on Sept. 19, with opening night planned for Oct. 15. The limited engagement is slated to play through Dec. 8.
Trip Cullman is directing the production. He and Tomei previously staged the show at Williamstown Theatre Festival in 2016.
Set in New Orleans, the play is about a widow who finds romance again.
No other cast members have been announced.
Tomei, 54, is known for her roles in the films My Cousin Vinny, The Wrestler, In the Bedroom and Untamed Heart. She will soon be seen in Spider-Man: Far From Home. She last appeared on Broadway in The Realistic Joneses in 2014.