American Beauty and The American President film actress Bening earned a Tony Award nomination for her Broadway debut in Coastal Disturbances in 1987. Her last New York stage job was acting opposite John Lithgow in the Public Theater's 2014 version of King Lear.
Letts is the Pulitzer Prize- and Tony Award-winning playwright of August: Osage County. The popular actor is also the author of the plays Bug, Killer Joe and Superior Donuts, which were all adapted for the screen.
Bening and Letts will begin performances in All My Sons on April 4, with an official opening night planned for April 22. Gregory Mosher is directing the play.
"In the aftermath of WWII, the Keller family struggles to stay intact and to fight for their future when a long-hidden secret threatens to emerge-forcing them to reckon with greed, denial, repentance, and post-war disenchantment across generations," the Roundabout said in a press release Thursday.
Additional cast members and design team will be announced soon, the producers said.