"This is going to be a weird party," Kimmel said on Twitter.
Kimmel will emcee the fundraiser and Khaled will provide the music at Garcetti's Sep. 25 event, which aims to raise $1 million -- $100,000 for races in 10 states -- in one night.
Those 10 states include California, Iowa, Nevada, New Hampshire, Michigan, Minnesota, Oklahoma, Ohio, Pennsylvania and Wisconsin.
The event is organized by the Democratic Victory Midterm Fund, a SuperPAC affiliated with Garcetti that seeks to elect more Democrats to Congress in races that are overlooked by the national party.
"I saw, among other things, the right wing in this country was pouring years of money and organizing and assistance into local and state parties and elections, and Democrats weren't," Garcetti told Variety. "We kind of woke up one day, not only with the White House not in our hands, but wondering why both houses of Congress, gubernatorial seats, and state legislatures suddenly weren't in Democratic hands, in a country where more Americans voted for Democrats than they do for Republicans."