The one-hour special will be taped primarily in Los Angeles with stages in New York and Nashville. Country music icon and Texas native George Strait will also offer a special performance from his own San Antonio benefit concert.
Hand in Hand will air ABC, CBS, CMT, FOX and NBC on Sept. 12. The show will also be available internationally via live stream on Facebook and Twitter starting at 8 p.m. EST.
"Hand in Hand will bring the country together to raise funds, spirits and help rebuild Texas in the wake of this unprecedented devastation," a press release said. "Proceeds from the telethon will benefit United Way of Greater Houston, Habitat for Humanity, Save the Children, Direct Relief, Feeding Texas and The Mayor's Fund for Hurricane Harvey Relief [administered by the Greater Houston Community Fund] through the Hand in Hand Hurricane Relief Fund managed by Comic Relief Inc."
Also working on the show are Houston native and rapper Bun B, talent manager Scooter Braun and celebrities Matt Lauer, Rob Lowe, Matthew McConaughey, Norah O'Donnell, Dennis Quaid, Julia Roberts, Kelly Rowland, Adam Sandler, Ryan Seacrest, Michael Strahan, Blake Shelton, Barbra Streisand and Reese Witherspoon.