The 45-year-old actress responded on Thursday's episode of Watch What Happens Live to lingering speculation about her marriage to the 48-year-old actor.
"That's the craziest [rumor about my family]," she said of reports that she and Smith are swingers, or a committed couple who engage in non-monogamous sexual activities together. "It's constant. I'm like, 'Yo, I wish! I wish.'"
Pinkett Smith married Smith in December 1997, but confirmed she and the actor have been together "23 years." She told host Andy Cohen the secret to her lasting relationship with Smith is their "amazing chemistry."
"I really think that Will and I just have amazing chemistry on a lot of different levels," the star shared. "We love to laugh together. We love to learn together. And we just love each other. We just have a good time together."
"I guess that's the secret -- we just really like each other," she concluded.
Pinkett Smith previously confirmed she and Smith, who share 19-year-old son Jaden and 16-year-old daughter Willow, have a kind of open marriage, or the freedom to sleep with other people.
"You gotta trust who you're with," the actress said on The Howard Stern Show in 2015. "I'm not his watcher. he's a grown man, and here's what I trust: I trust that the man that Will is is a man of integrity, so he's got all the freedom in the world."
"As long as Will can look at himself in the mirror and be okay, I'm good," she added. "Just because your man is attracted to another woman does not mean he doesn't love you ... and it doesn't mean he's going to act on it."