"I wake up every morning and it's like when you break up with somebody who has really broken your heart," the pop icon said in a new cover story published Tuesday from Harper's Bazaar.
"You wake up and for a second you're just you, and then you go, 'Oh, the person I love more than anything has just broken my heart, and I'm devastated and I'm broken and I have nothing. I'm lost.' That's how I feel every morning. I wake up and I go, 'Wait a second. Donald Trump is the president. It's not a bad dream. It really happened.' It's like being dumped by a lover and also being stuck in a nightmare," she continued.
Madonna said she plans on getting more political and speaking out more during Trump's presidency.
"I have to get way more vocal and become a little bit less mysterious," the 58-year-old said, noting that others in the music industry will remain silent.
"What I find really astonishing is how quiet everybody is in my industry. I mean, nobody in the entertainment business except for maybe a handful of people ever speak out about what's going on. Nobody takes a political stance or expresses an opinion," Madonna noted.
"Everyone's really afraid. Because it doesn't affect their daily life yet, no one's doing anything about it."
Madonna, a noted Hillary Clinton supporter, slammed Donald Trump before in interviews and during a December concert in Miami where she covered Britney Spears' 2003 hit "Toxic" as images of Trump were projected behind her.
"I'm not being too opinionated? Too extreme? I'm not insulting anyone? I must not be doing something right," she said to the audience.