The 28-year-old Rob & Chyna star turned out for the event at Pershing Square in Los Angeles, along with Kendra on Top star Kendra Wilkinson, Rose's Dancing with the Stars partner, Maksim Chmerkovskiy and thousands of fans.
Rose led the walk to promote her foundation's mission of "uplifting, empowering and enhancing the platform of women across the globe." Other organizations have also put on SlutWalks to call for an end to slut-shaming.
"This is the no judgment zone. We're out here, we're embracing everyone, this is very positive and very loving," Rose told Entertainment Tonight. "It's important to feel self-confident, because that's what gets you through the day and through your life."
"[I'm] overwhelmed with happiness [by the support]," she added. "I, like, almost cried for a second. I probably will cry throughout the day. It's beautiful, it really is, and I'm happy that I have all this support."
Rose hosted her first SlutWalk in October 2015. The Dancing with the Stars Season 23 contestant had said last week that she felt body shamed by judge Julianne Hough after her and Chmerkovskiy's performance to "Booty."
"[There] was a point in the dance where I had to lift my leg up and Maks dipped me & [Julianne] said, 'Oh, I'm uncomfortable,' and I instantly, I did feel body shamed," she said on her Loveline podcast.
"All the beautiful professional dancers ... they dress very sexy and they do splits and they grind up on these guys and they look absolutely stunning -- and they get a standing ovation," the star added. "For me and my body -- my hips, my [expletive], my breasts -- made her feel 'uncomfortable.'"