The 32-year-old actress commented on the 36-year-old actor's romance with Kelly, her close friend, while appearing on Tuesday's episode of Watch What Happens Live.
"We're all close friends," she told host Andy Cohen. "No, it's not weird. I love them both, and I've been friends with [Wilmer] for 15 years. We're like, very, very close friends."
Moore and Valderrama dated in the early 2000s and have remained friendly since. Valderrama and Kelly reportedly dated in 2012 and sparked rumors of a reconciliation in August.
"He's a good friend to me," Kelly said on The Cruz Show on Power106 this month. "We are good friends and we always have been. It's funny, this whole 'back with my ex thing.' We're not exes."
"Wilmer's a really, really good person and I think any girl would be lucky to have him," she added.
Valderrama had split from singer Demi Lovato in June after six years of dating. Moore, meanwhile, finalized her divorce from Ryan Adams the same month after separating from the singer in 2014.