The athletic wear company confirmed as much in a statement Wednesday after West declared his 18-year-old sister-in-law would never collaborate with the brand last week.
"I am pleased and excited to be able to confirm that Puma is indeed working with Kylie Jenner," global director of brand and marketing Adam Petrick said.
"Kylie will be featured in the brand's spring/summer women's training campaign launching in April 2016. Kylie represents a fresh and exciting new era for fashion and we couldn't think of a more fitting and influential female to headline this campaign."
West, who designs for Puma rival Adidas, had told his 19 million Twitter followers Jenner won't work for the company out of a sense of loyalty. The 38-year-old rapper married the teenager's half-sister Kim Kardashian in 2014.
"1000% there will never be a Kylie Puma anything. That's on my family! 1000% Kylie is on Yeezy team!!! Puma we gone give you your measly million dollars back!!! Never try to divide the family!!!" he tweeted Feb. 9.
West admitted he was "mad for a little bit" in an interview with TMZ on Wednesday, but said he's "really happy" for Jenner now. The rapper is under fire after being recorded having a meltdown prior to his recent Saturday Night Live appearance.