The 43-year-old actress discussed the possibility in the Feb. 4 issue of Net-a-Porter magazine. Vergara is already mom to 23-year-old son Manolo with her first husband, but revealed she and 39-year-old Manganiello are considering having kids of their own.
"I became a mother very young -- at 20 -- so I feel like I've been a mother my whole life," the star said. "Now that I'm 43 and my son is 23, it's funny to see some of my girlfriends raising young kids. In the US, women postpone motherhood, but in Latin America most of my friends have kids my son's age."
"I wouldn't mind another child: my husband is younger than me and he wants kids so we're trying to figure out what we're going to do," she shared. "The idea of doing it all again doesn't scare me but, hey, it's not like it's going to happen naturally, is it?"
Vergara is open to in-vitro fertilization, having previously frozen embyros with ex-fiancé Nick Loeb. Having more children wasn't high on the actress' list of priorities, however, when she spoke to Cosmo Latina magazine in summer 2015.
"When you're with somebody that hasn't had kids and you want to start a relationship, of course there's always that question," she explained. "And if it it happens, it will be something that will make us very happy, but it's not a priority in our lives."
Vergara and Manganiello have been together since mid-2014 and married in Palm Beach, Fla., in November. The actress plays Gloria Delgado-Pritchett on ABC sitcom Modern Family, while Manganiello will next star in Pee-wee's Big Holiday.