The 40-year-old actor discussed his dynamic with the 25-year-old actress in an interview Wednesday on The Howard Stern Show. Cooper told Stern his relationship with Lawrence will remain platonic, despite their chemistry and many film collaborations.
"It's really due to [director] David O. Russell," he explained of his connection with the actress. "We did Silver Linings Playbook together. We got along great."
"[We'll] never [have sex] ... It just didn't happen," he said of a potential romance. "It's not the way we are together."
Cooper and Lawrence also co-starred in American Hustle and Serena, and will reunite in the forthcoming movie Joy. The film opens in theaters Dec. 25, and dramatizes the real-life story of Joy Mangano, the inventor of the Miracle Mop.
"I've sort of hit the jackpot [in] being able to work with Jennifer Lawrence," the actor told Vanity Fair last year. "Her probably biggest asset is her level of relaxation when she acts. It's a very thrilling thing to be a part of, as a partner in the scene [who] takes you into the scene."
Cooper will next appear in Burnt with Sienna Miller, and is also slated to reprise Rocket for Guardians of the Galaxy 2. Lawrence will star in The Hunger Games: Mockingjay - Part 2 in November, and is scheduled for X-Men: Apocalypse in 2016.