Meester and Brody met on the set of The Oranges in 2010 and married in February 2014. Word the couple were expecting broke in May, but the pair never confirmed the actress' pregnancy.
The actor declared his "infinite" love for Meester during a Reddit AMA last year, revealing the star does the figurative "heavy lifting" in their relationship. He also joked he wants to have "12" kids with the actress.
Meester is best known for portraying Blair Waldorf on The CW series Gossip Girl, while Brody came to fame as Seth Cohen on the Fox drama The O.C. The actress will next appear in Like Sunday, Like Rain with Debra Messing, with Brody scheduled for Yoga Hosers with Johnny Depp.