The 32-year-old actress portrays an e-commerce fashion CEO named Jules who reluctantly takes on retired widower Ben, played by the 71-year-old De Niro. The pair form a friendship after Jules' skepticism of her aging intern gives way to respect.
The film is directed by What Women Want and Something's Gotta Give helmer Nancy Meyers, and opens in theaters September 25. Rene Russo co-stars as Ben's love interest Fiona, with Adam DeVine, Nat Wolff and Reid Scott in supporting roles.
Hathaway is also scheduled for The Burning Woman, and will reprise the White Queen in Alice Through the Looking Glass. De Niro is slated for Bus 657 with Jeffrey Dean Morgan, Joy with Jennifer Lawrence and Dirty Grandpa with Zac Efron.