The 89-year-old Playboy founder broke his silence on Madison's book, Down the Rabbit Hole: Curious Adventures and Cautionary Tales of a Former Playboy Bunny, in a statement to E! News.
"Over the course of my life I've had more than my fair share of romantic relationships with wonderful women," he shared. "Many moved on to live happy, healthy and productive lives, and I'm pleased to say remain dear friends today."
"Sadly, there are a few who have chosen to rewrite history in an attempt to stay in the spotlight," he said of Madison. "I guess, as the old saying goes: You can't win 'em all!"
Madison painted a largely unflattering portrait of Hefner and fellow former girlfriend Kendra Wilkinson in the memoir. The 35-year-old star alleged the Playboy founder offered her drugs and pitted the girlfriends against each other, and slammed Wilkinson as a "coward" and "fake."
"I wanted to share my story to inspire other women who might be in a bad relationship to get out, or not to be branded by bad decisions they've made, and take charge of their lives and move on," she told ET. "I'm definitely not rewriting history. I'm finally telling the truth of my experience."
Down the Rabbit Hole hits bookshelves Tuesday. Madison was Hefner's official girlfriend from 2001 to 2008, and went on to appear on season 8 of ABC reality competition Dancing with the Stars and star on E! reality series Holly's World.