The show will broadcast live from Los Angeles' Shrine Auditorium Sept.21.
Falco, who has already won two Emmys for her recurring role in "The Sopranos," is nominated for her role as Carmela Soprano again this year.
Falco is the only actress to ever receive an Emmy, a Golden Globe and a SAG award for her work on a television show, all in the same year.
Gandolfini earned his third Emmy nomination for his role as Tony Soprano, a role for which he won consecutive Emmys in 2000 and 2001.
His portrayal of a mob boss on the Sopranos has also won him a Golden Globe and two SAG awards. He also was named American Film Institute's Television Actor of the Year in 2001.