McCoy departed the game after his second run. The six-time Pro Bowl selection took a handoff to the left sideline where he was met by Colts cornerback Kenny Moore II. The defensive back hit McCoy into the air, where he fell out of bounds awkwardly.
McCoy's head hit the ground hard during the fall. He managed just one yard on his two carries prior to his departure.
The Bills star entered the game with 243 yards on 61 carries this season. He has not scored a touchdown.
Chris Ivory took over the Bills' lead running back role following McCoy's exit.