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Vice President George Bush announced the resignation of a...

WASHINGTON -- Vice President George Bush announced the resignation of a top adviser Tuesday and installed a former campaign loyalist to serve as his new deputy chief of staff and assistant for policy.

Bush announced that Fred Khedouri is resigning and will be replaced, effective March 16, by Charles Greenleaf, an assistant administrator of the Agency for International Development.

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Greenleaf, 45, served as an assistant to President Gerald Ford and as deputy staff director to Bush in the 1980 campaign. Before joining the administration, he was assistant director of the Institute of Politics at Harvard University.

The Greenleaf appointment came at a time when Bush has stepped up his campaigning for the 1988 GOP presidential nomination. The staff realignment announced Tuesday included the following changes as well:

-Thomas Collamore, who has served for almost two years as deputy assistant and staff secretary to the vice president, was promoted to the position of assistant for operations. In that job, Collamore will oversee administration, handle the flow of paperwork and serve as a liaison with the White House senior staff.

-Hector Irastorza, a member of the Bush advance team since December 1985, was named deputy assistant for scheduling. He replaces Deborah Hutton, who is resigning.

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-John Keller, deputy director of the Bush advance team since last year, was named to head that staff. Keller joined the Bush advance staff in 1982 and was active in the Bush campaign in 1980.

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