William Holmes McGuffey (September 23, 1800 – May 4, 1873) was an American professor and college president who is best known for writing the McGuffey Readers, one of the nation's first and most widely used series of textbooks. It is estimated that at least 122 million copies of McGuffey Readers were sold between 1836 and 1960, placing its sales in a category with the Bible and Webster's Dictionary.
He was born the son of Alexander and Anna (Holmes) McGuffey near Claysville in Washington County, Pennsylvania, which is 45 miles southwest of Pittsburgh. In 1802 the McGuffey family moved further out into the frontier at Tuscarawas County, Ohio. He attended country school, and after receiving special instruction at Youngstown, he attended Greersburg Academy in Darlington, Pennsylvania. Afterwards, he attended and graduated from Pennsylvania's Washington College, where he became an instructor.
He was close friends with Washington College's President Andrew Wylie and lived in Wylie's house for a time; they often would walk the 3 miles to Washington College together.