The William J. Clinton Foundation is a foundation established by former President of the United States Bill Clinton with the stated mission to "strengthen the capacity of people throughout the world to meet the challenges of global interdependence." The Foundation focuses on four critical areas: health security; economic empowerment; leadership development and citizen service; and racial, ethnic and religious reconciliation. The Foundation works principally through partnerships with like-minded individuals, organizations, corporations, and governments, often serving as an incubator for new policies and programs. They have offices located in Harlem, New York City; Boston, Massachusetts; and Little Rock, Arkansas.

The Clinton Foundation HIV/AIDS Initiative (CHAI) strives to make treatment for HIV/AIDS more affordable and to implement large-scale integrated care, treatment, and prevention programs. Since its inception, CHAI has helped bring AIDS care and treatment to over 750,000 people living with HIV/AIDS around the world. Its activities have included AIDS care and treatment in Africa, including the brokering of drug distribution agreements. During President Clinton's 2006 trip to Africa, CHAI signed agreements with several new countries. Over the course of the past year, CHAI has expanded its partner countries and members of the Procurement Consortium to over 70 including 22 governments, who are now able to purchase AIDS medicines and diagnostic equipment at CHAI’s reduced prices.

CHAI launched the Pediatric and Rural Initiatives in 2005 to focus on bringing AIDS care and treatment to those most often marginalized— children and those living in rural areas. CHAI also negotiated agreements that reduce the prices of second-line drugs and rapid diagnostic tests. In May, 2007, CHAI and UNITAID announced agreements that help middle-income and low-income countries save money on second-line drugs. The partnership also reduced the price of a once-daily first-line treatment to less than $1 per day.