Uncle Dave Macon (October 7, 1870 — March 22, 1952)—also known as "The Dixie Dewdrop"—was an American banjo player, singer, songwriter, and comedian. Known for his chin whiskers, plug hat, gold teeth, and gates-ajar collar, he gained regional fame as a vaudeville performer in the early 1920s before going on to become the first star of the Grand Ole Opry in the latter half of the decade. Macon's music is considered the ultimate bridge between 19th-century American folk and vaudeville music and the phonograph and radio-based music of the early 20th-century. His polished stage presence and lively personality have made him one of the most enduring figures of early country music.

David Harrison Macon was born in Smartt Station, Tennessee (about 5 miles south of McMinnville), the son of Confederate Captain John Macon and his wife Martha Ramsey. In 1884, when young David was thirteen years old, his family moved to Nashville, Tennessee to run the Old Broadway Hotel, which they had purchased. The hotel became a center for Macon and his growing musical interests, as it was frequented by artists and troupers traveling along various vaudeville circuits and circus acts. In 1885, he learned to play the banjo with the assistance of a circus comedian called Joel Davidson. While in Nashville, he attended Hume-Fogg High School. A tragedy struck the Macon family when his father was murdered in 1886 outside the hotel. The hotel was sold and the family quickly moved to Readyville, Tennessee, where his mother ran a stagecoach stop. Macon began entertaining the passengers who arrived at the rest stop by playing the banjo from a home made stage.

In 1889, Macon married Matilda Richardson and moved to a farm near Kittrell, Tennessee, where they in time raised six sons. Around 1900, Macon opened a freight line between Murfreesboro and Woodbury, Tennessee. It was called The Macon Midway Mule and Wagon Transportation Company. Often, when Macon was driving along with his mules, hauling freight and produce, he would entertain people by singing and playing the banjo at various stops along the way. In time, his sons became part of the company as they grew up. But the arrival of an automobile-based competitor threatened his mule company, and he was forced to close down in 1920.