Tyler Palko (born August 9, 1983 in Imperial, Pennsylvania) is an American football quarterback for the Arizona Cardinals of the National Football League. He was signed by the New Orleans Saints as an undrafted free agent in 2007. He played college football at Pittsburgh.

Palko attended West Allegheny High School in Imperial, Pennsylvania. Palko was the Associated Press 2001 Pennsylvania Big School Player of the Year at West Allegheny. He was a USA Today All-America Team (second team) and three-time Pittsburgh Post-Gazette WPIAL Class AAA Player of the Year. Palko also led his West Allegheny Indians to a PIAA state title in 2001 for AAA in Pennsylvania. At West Allegheny he played under his father in foot, Coach Bob Palko, earning four letters in football; additionally he earned three letters in basketball, and one in track and field. In his high school senior year, he was named 2002 YMCA Tribune-Review Scholar-Athlete honoree. In 2002, Palko was selected to play in the U.S. Army All-American Bowl, an all-star game for high school athletes.

Palko played for the University of Pittsburgh football team, where he started his career in 2002 as a lettered true freshman. He only completed 2-3 passes for 13 yards on the season, but rushed for an eight-yard touchdown late in Pitt's Insight Bowl victory over Oregon State.