Thomas J. Donohue is the President and CEO of the United States Chamber of Commerce located in Washington, DC. The US Chamber of Commerce is one of the largest business associations in the world. Before joining the Chamber in 1997, Donohue was the President and CEO of American Trucking Associations for 13 years.

The United State Chamber of Commerce is a non-partisan lobbying group that supports pro-business causes. As its president, Donohue has increased the Chamber's profile in Washington.

The New York Times writes that “through Mr. Donohue’s efforts, the Chamber has become the most visible and effective business lobby in the country.” The Washington Post says “Nobody has mastered the new Washington game better than Tom Donohue.”