Takeo Gerard Spikes (pronounced /təˈkiːoʊ/; born December 17, 1976 in Sandersville, Georgia) is an American football linebacker for the San Francisco 49ers of the National Football League. He was drafted by the Cincinnati Bengals 13th overall in the 1998 NFL Draft. He played college football at Auburn.
A two-time Pro Bowl selection, Spikes has also played for the Buffalo Bills and Philadelphia Eagles.
In high school at Washington County High School in Georgia he earned All-American honors from Parade and USA Today and was named Georgia's "Mr. Football" by state coaches as a senior. Spikes was also named Georgia Player of the Year as a senior.