Sean O'Keefe (born January 27, 1956) is the CEO of EADS North America, a subsidiary of the European aerospace firm EADS, a former Administrator of NASA, and former chancellor of Louisiana State University (LSU). O'Keefe is also a former member of the board of directors of DuPont. He resigned from LSU on January 16, 2008.
Asteroid 78905 Seanokeefe was named after him in honor of his time as NASA Administrator.
O'Keefe and his teenaged son were among four survivors of a plane crash on August 9, 2010 near Aleknagik, Alaska. O'Keefe sustained serious injuries in the crash of a de Havilland Canada DHC-3 Otter seaplane in which former United States Senator Ted Stevens and four others perished.