Santonio Holmes, Jr. (born March 3, 1984, in Belle Glade, Florida) is an American football wide receiver for the Pittsburgh Steelers of the National Football League. He previously played college football with the Ohio State Buckeyes.

Holmes attended Glades Central High School in Belle Glade and was a letterman in football, basketball, and track. In football, he helped lead his team to two state titles and a 12-1 record as a senior. In basketball, he helped lead his team to a state runner-up finish as a senior. In track, his team won the state title during his junior year, and he was the member of a 4x400 meter relay team that won two state titles. Santonio graduated from Glades Central Community High School in 2002 with a 3.4 GPA.

Holmes started at receiver for The Ohio State University from 2003 to 2005, catching 245 passes for 2,295 yards and 25 touchdowns, while gaining 3,123 all-purpose yards. His 240 career receptions and 3,496 yards ranked were the fifth totals highest in school history at the time he left the Buckeyes in 2005. His 25 touchdown catches ranked him third. He majored in general studies.