Sally Hemings (Shadwell, Albemarle County, Virginia, circa 1773 – Charlottesville, Virginia, 1835) was an African-American slave owned by Thomas Jefferson. She was said to have been the half-sister of Jefferson's wife Martha Wayles Skelton Jefferson. Journalists and others alleged during the administration of President Jefferson that he had fathered several children with Hemings after his wife's death. Late 20th century DNA tests indicated that a male in Jefferson's line, likely Thomas Jefferson himself, was the father of at least one of Sally Hemings's children.

Hemings's mother, Elizabeth Hemings, was the daughter of the English captain Hemings and an enslaved African woman. Along with other members of her family, she was owned by Jefferson's father-in-law, John Wayles, who died in 1773. He left nearly all members of the Hemings family to his daughter Martha Jefferson.

Several sources assert that Sally Hemings was a half-sister to Martha, both fathered by John Wayles, which is generally accepted, but not undisputed. Wayles had lost three wives by the time of his relationship with Betty Hemings, and he was said to have had several children with her, of whom the youngest was Sally. The Hemings family were light-skinned and multiracial, at the top of the slave "hierarchy" at Monticello in terms of their domestic work assignments.