Rosanna Lauren Arquette (born August 10, 1959) is an American actress, film director, and film producer.

Arquette was born in New York City, the daughter of Brenda "Mardi" Olivia (née Nowak), an actress, poet, theater operator, activist, acting teacher and therapist, and Lewis Arquette, an actor and director. Arquette's paternal grandfather was comedian Cliff Arquette. Arquette's mother was Jewish, the daughter of a Holocaust refugee from Poland, and Arquette's father was a convert to Islam and claimed to be a descendant of explorer Meriwether Lewis. Arquette's siblings are actors Patricia, Alexis, Richmond and David Arquette. Arquette is also the sister-in-law of Courteney Cox, who is married to Arquette's brother David.

In 1963, Arquette's family moved to Chicago, where her father managed The Second City theater for several years. When she was eleven years old, her parents moved to a commune in Front Royal, Virginia. Arquette did not do well at school. In 1974, she hitchhiked across the country with three older teenagers, eventually going to San Francisco, where she worked at renaissance and Dickens fairs. Her professional theater debut was May 27, 1977, appearing in the Story Theatre Musical production of Ovid's The Metamorphoses at the Callboard Theatre on Melrose Place in Los Angeles.