Ronald "Ron" Klein (born July 10, 1957) is an American politician from the U.S. state of Florida. Klein, a Democrat, served in the Florida House of Representatives from 1993 to 1996 and in the Florida Senate from 1996 till 2006, where he was the Senate minority leader.

Klein was elected in the 2006 House election in Florida's 22nd congressional district, defeating 13-term Republican incumbent Clay Shaw. He took office on January 4, 2007.

Klein was born in Cleveland, Ohio. He graduated from Cleveland Heights High School in 1975, and attended The Ohio State University, graduating with a Bachelor of Arts degree in political science in 1979.