Rocco DiSpirito (born November 19, 1966 in Jamaica, Queens, New York City, New York) is an American chef based in New York City. He is a 1986 graduate of the Culinary Institute of America in Hyde Park, New York, and a 1990 graduate of Boston University with a bachelor's degree in business. DiSpirito is known for his Italian-American cuisine and his innovative fusion cooking; his mother, Nicolina, is known for her Italian meatballs.

DiSpirito is best known as a celebrity chef and a cookbook author. He is known for his involvement in Union Pacific, a restaurant he opened in 1997 in the Gramercy Park section of Manhattan. A year later, New York Times reviewer Ruth Reichl, in an ecstatic three-star review, reported that a woman at the next table was moaning in uncontrollable ecstacy as she ate, but it was impossible to determine what dish had provoked that reaction, since just about every entree was worthy of such moans. He left Union Pacific in 2004. In 2003 and 2004, DiSpirito was the subject of the NBC reality television show The Restaurant, which followed DiSpirito and his mother, Nicolina during the opening of their restaurant, Rocco's 22nd Street.

DiSpirito hosted his own radio talk show for WOR from October 2004 through December 2005, and currently hosts a TV show called "Rocco gets Real" on A&E.