This article is about the 2008 Metrolink train collision in Los Angeles, for the 1887 train collision at Great Chatsworth, Illinois, see 1887 Great Chatsworth train wreck.

The 2008 Chatsworth train collision occurred at 16:22 PDT (23:22 UTC) on Friday September 12, 2008, when a Union Pacific freight train and a Metrolink commuter train collided head-on in the Chatsworth district of Los Angeles, California, in the United States. The scene of the accident was a curved section of single track on the Metrolink Ventura County Line just east of Stoney Point.

Before the collision, the Metrolink train may have run through a red signal before entering a section of single track where the opposing freight train had been given the right of way by the train dispatcher. The Metrolink train's engineer was near the end of a work week of long split shifts, making fatigue a subject of the investigation, along with distraction from text messages he was sending while on duty. The accident remains under investigation; meanwhile the basic circumstances have been released to the public, but the official report determining probable cause is expected to take up to a year to complete.