Rei Kawakubo (川久保 玲, Kawakubo Rei?, born 1942-10-11 in Tokyo) is a Japanese fashion designer, founder of Comme des Garçons.

She is untrained as a fashion designer, but studied fine arts and literature at Tokyo's prestigious Keio University. After graduation, Kawakubo worked in a textile company and began working as a freelance stylist in 1967.

In 1973, she established her own company, Comme des Garçons Co. Ltd in Tokyo and opened up her first boutique in Tokyo in 1975. Starting out with women's clothes, Kawakubo added a men's line in 1978. Three years later, she started presenting her fashion lines in Paris each season, opening up a boutique in Paris in 1982.